The BAG4 Antibody (C-term) from MyBioSource.com is a Rabbit Polyclonal antibody to BAG4, and SODD. This antibody recognizes Human antigen. The BAG4 Antibody (C-term) has been validated for the following applications: ELISA, and Western Blot.
Description
BAG4 is a member of the
BAG1-related protein family. BAG1 is an anti-apoptotic protein that
functions through interactions with a variety of cell apoptosis and
growth related proteins including BCL-2, Raf-protein kinase,
steroid hormone receptors, growth factor receptors and members of
the heat shock protein 70 kDa family. This protein contains a BAG
domain near the C-terminus, which could bind and inhibit the
chaperone activity of Hsc70/Hsp70. This protein was found to be
associated with the death domain of tumor necrosis factor receptor
type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively
regulates downstream cell death signaling. The regulatory role of
this protein in cell death was demonstrated in epithelial cells
which undergo apoptosis while integrin mediated matrix contacts are
lost